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The 10 Highest THC Strains You'll Want to Try

The use of cannabis is a very personal experience. What works well for you and produces a desirable effect may not be the right fit for someone else. This makes sense, of course, when we remember each brain, body, and nervous system is unique. For instance, some people are more prone to anxiety, while others may experience persistent fatigue.

One way to accommodate these differences using cannabis is to adjust the strength of the THC or CBD strains being used.

The intensity of marijuana effects depends on the number of chemical compounds found in a particular strain. For example, the highest THC weed strains produce the most psychoactive effects, like altered time perception, laughter, hunger, etc.

Let’s take a closer look at some of the highest THC strains on the market today, along with the strength and benefits of each strain.

What is considered a high THC strain?

As a general industry rule of thumb, any strain that contains 20% THC or more is considered “high THC.” Novices should be mindful when consuming a strain with this level of THC. 

High THC strains are ideal for those with a strong marijuana tolerance, people looking for pain relief, or those with medical conditions that cause severe, debilitating symptoms.

What are the benefits of high THC strains?

Several positive outcomes might influence a person’s decision to explore the strongest weed strains. These benefits include:

1. Chronic Pain Relief

Strong weed strains are ideal if you suffer from severe chronic pain. Whether your discomfort is caused by rheumatoid arthritis, fibromyalgia, pulled muscles, migraines, or cancer, high levels of THC can ease the intensity of your pain and make everyday tasks and activities more tolerable.

In fact, one study found potent THC strains to be as effective as opioids and other common treatments for reducing pain levels. And while there are still some concerns, such as dizziness and impaired motor function, many patients feel these side effects are far more manageable.

2. Reduced Fear in PTSD Patients

PTSD often prohibits people from functioning as they normally would on an everyday basis. Night terrors, flashbacks, insomnia, depression, and anxiety are a few of the PTSD symptoms that can disrupt a person’s life and make it difficult to work, maintain relationships, or even simply experience happiness. 

Fortunately, studies have shown THC to be effective not only at alleviating the severity of PTSD symptoms but also at improving the likelihood of recovering from the condition (people who use marijuana are 2.5x more likely to regain a healthy quality of life)

3. Elevated Mood

If you have been diagnosed with depression or anxiety, high-THC weed may be the ideal solution. Potent strains are more likely to induce a euphoric sensation, so you may expect to giggle, melt into the couch, and unwind as your worries melt away. Just be sure to look for strains that uplift without being overly stimulating, as these can increase the likelihood of anxiety.

4. Appetite Stimulant

Numerous medical conditions can cause a person’s appetite to diminish. If you struggle with keeping food down due to nausea, chemo, or cancer or find it challenging to maintain a healthy eating routine, THC can help. Several of the highest THC strains are known to induce hunger, sending consumers on a mad dash to their snack cupboards. 

5. Improved Sleep Quality

According to the American Sleep Association, 30 percent of American adults experience short-term insomnia at some point in their lives, and approximately 10 percent experience long-term insomnia. That’s a significant number at more than 70 million people.

Cannabis has been shown to improve sleep quality among those who have insomnia. In fact, in one study, cannabis users reported their sleep quality improved by as much as 80 percent. If an inability to sleep has negatively impacted your life for several weeks or months, a high THC strain may benefit you.

10 of the Highest THC Strains

1. Tally Man #3

This is one of the most potent weed strains consumers will find in medical cannabis dispensaries — but don’t let its elevated levels intimidate you. Tally Man #3 is a hybrid that combines CBD and THC in perfect harmony. You’ll enjoy the cerebral benefits of THC, like a slowed perception of time and greater amusement, as well as the relaxing bodily effects of CBD. 

THC Level


Flavor Profile 

Since Tally Man strains are a cross between Banana OG and Do-Si-Do, you can expect to taste the sweetness of banana and the earthy, spice-forward notes that Do-Si-Do is famed for.

Best Known For

Transporting consumers into a deep state of tranquility. This isn't the right strain for you if you’re hoping to get chores done around the house (or accomplish much of anything, really). But it will slow those racing thoughts and make your body feel like it’s made of Jell-O. 

2. Papaya

Papaya is an indica-dominant hybrid known to catch novice cannabis users off guard. It isn’t at the top of the list for strongest strains in terms of percentage, but it is potent in terms of effectiveness. At first, Papaya boosts energy and uplifts your mood, making you chatty and upbeat. But look out for the half-hour mark! The sedative effects of indica will sneak up on you, and you’ll be ready for a nap in no time.

THC Level


Flavor Profile

This is a sweet, citrus strain with a strong sour fragrance. When smoked, the sour smell dissipates and is replaced with a smooth, slightly peppery smolder.

Best Known For

Alleviating anxiety. Consumers celebrate Papaya for producing a mellow mental effect that isn’t overly intense. It’s low in CBD, so body sensations are minimal. You’ll still be able to get up off the couch and fix yourself a meal or go for a walk, but your mood will be light and happy-go-lucky.

3. Candy Margy

This is a well-balanced hybrid that offers the focus of your favorite sativa strains with the warm, floaty feeling you’d get from an indica. It’s achieved by crossing Wedding Pie (an indica-dominant hybrid known for its powerful head high) with Frozen Margy (ultra mood-lifting), which results in a euphoric, cerebral smoking experience.

THC Level


Flavor Profile

You can expect the slightly acidic flavor of orange and apricot, with sweet overtones of vanilla and a herbal taste on the exhale. 

Best Known For

It’s energetic and giggly high. This strain is a definite mood booster and also delivers moderate pain relief. A fantastic option for those experiencing fatigue, depression, or mild-to-moderate aches and pains.

4. Lava Cake

If you’re looking for one of the strongest weed strains on the indica-leaning list, Lava Cake is likely to impress. It makes the body feel completely at ease without the numbing effect of more potent indicas, which can render you immobile for hours. Lava Cake is also great for those seeking enhanced creativity or deep thought, as it’s known to leave consumers contemplating the universe and all its mysteries.

THC Level


Flavor Profile

The name of this strain is incredibly accurate in terms of flavor. You’ll be delighted by a rich, chocolatey taste upon inhalation, followed by a refreshing hint of fresh pine as you breathe out.

Best Known For

Being a chill, calming, and thoughtful high that’s best enjoyed in the evening. Infuse water with flower to create a soothing cup of tea for a restful night’s sleep. Suffer from headaches? This strain is also quite popular amongst cannabis enthusiasts seeking migraine relief.

5. Apple Cookies

Sweet, fruity, and super-satisfying — Apple Cookies is a dependable strain that will leave you smiling from ear to ear. It’s one of the highest THC sativa strains on the market, so your mood and energy levels will increase significantly.

THC Level


Flavor Profile

You’ll immediately notice the crisp, juicy apple citrus notes, which quickly subside and leave behind a light, honeyed sweetness you’ll definitely want to savor. There’s also a distinctive herbal aroma to this strain when it’s fresh, but the juicy sweetness of apples replaces it upon being ignited.

Best Known For

Being a delightful day-time treat that won’t prevent you from being productive. Clean the house, cook a meal, or respond to emails — you’ll be able to do it all without crashing or needing to lie down.

6. Sundae Driver

Aromatic and smooth, Sundae Driver isn’t just one of the highest THC weed strains — it’s also one of the most popular. It’s a hybrid that leans more towards indica, producing a tranquil body high that reduces pain levels and provides a comfortable experience. Just be aware it can cause sleepiness if consumed in large amounts.

THC Level


Flavor Profile

Sweet and slightly tart, with hints of grape and berries. There’s a rich, toasted espresso aroma while the flower is still fresh, which quickly dissipates for a light and luscious smoke.

Best Known For

Effectively treating chronic pain with just a couple of tokes. Muscles and joints feel loose, effortless, and free from discomfort. A truly cloud-like experience!

7. Super Glue Haze #12

Always a fantastic choice for fans of sativa-dominant hybrid strains, Super Glue Haze provides euphoric effects that last longer than many of its competitors. It’s also one of the highest terpene strains in terms of caryophyllene — which is responsible for the spicy flavor profile of this strain and its anxiety-reducing effect.

THC Level


Flavor Profile

A pleasing mix of lemon citrus, black pepper, and diesel fumes — this is a pungent strain that releases a powerful waft as soon as you open the bag. But don’t worry. The smoke is lush and mellow.

Best Known For

Deep relaxation. This isn’t a strain you want to smoke before heading out to meet up with friends or attempting to finish that home project you’ve been putting off. It’s quite tranquilizing, so it’s best used before bed or a serious couch session.

8. MAC

This highly sought-after, balanced hybrid strain has frosted, glistening trichomes, giving it a snow-covered appearance. It produces a spine-tingling body high that’s noticeable without being overwhelming. It’s also known to lift spirits and send consumers into fits of laughter. However, you should note that the come-down has the opposite effect and will likely leave you feeling sleepy.

THC Level


Flavor Profile

Think of MAC as the orange creamsicle of cannabis. It provides a heavenly blend of vanilla, citrus, and herbs but gets stronger on the finish with a powerful, earthy exhale.

Best Known For

A consciousness-expanding high that enhances creative thinking. You won’t feel overly sedated after smoking MAC, so you can still engage in activities you enjoy, like puzzles or video games. But you still get the benefit of feeling more relaxed and content.

9. Kush Mints

An evenly-balanced hybrid with mild mood-elevating effects. An ideal strain for relaxed environments. Have deep conversations with old friends, listen to your favorite vinyl record, or pour yourself a bath and forget the world exists. Kush Mints is comforting, like a warm blanket at the end of a long day.

THC Level


Flavor Profile

Fresh and woodsy to start, Kush Mints reveals a more robust coffee flavor as it burns. It’s equal parts exhilarating and soothing for a smoking experience that’s memorable in the best way. 

Best Known For

A carefree escape from the stresses of everyday life. Just a couple of tokes is all you’ll need to tune out the world and feel all the tension in your body slowly disappear.

10. Banana Runtz

Last but not least, this fan-favorite hybrid tops off our list of highest THC strains. It’s known for providing a clear cognitive high that promotes focus while simultaneously relaxing the body and taking the edge off any headaches, sore muscles, or joint stiffness. 

THC Level


Flavor Profile

A subtle nuttiness that’s enhanced with the sweetness of banana. Provides a stronger, tobacco-like finish that adds an interesting complexity to the overall taste.

Best Known For

Being a reliable pain reliever and putting consumers in a cheerful mood. It’s also a highly-effective appetite stimulant, so have plenty of munchies on standby!

Now that you’re familiar with a few of the most popular high-THC strains on the market right now, why not try some for yourself to determine which cannabis products best suit your needs?

Start your search with us

At WholesomeCo, we’re on a mission to normalize cannabis as a natural path to health and wellness. We believe in putting the needs of our patients first and maintaining an inventory of industry-leading cannabis products to provide them with the best possible solutions. Because when you have access to information and products you can trust, you can make better decisions for your well-being.

One of our experienced and highly-knowledgeable pharmacy agents will be happy to assist you in finding cannabis flower, edibles, vape cartridges, etc., that address your concerns and provide your ideal experience. Reach out to us today and begin your wholesome journey to wellness.  

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